HMG for male fertility

follicle stimulating hormone

If you are trying to conceive, HMG may be a good option for you. HMG is short for human menopausal gonadotropin, and it is a hormone that is used to help stimulate the production of sperm. HMG therapy is becoming an increasingly popular treatment for male infertility, and there are many different brands of HMG available on the market. In this blog post, we will discuss everything you need to know about HMG therapy for male fertility!

What Is Clomiphene?

Clomid is a brand name for clomiphene and is currently FDA-approved for female infertility, although doctors may also prescribe it to males off-label. It’s typically given to men with low sperm counts as a result of low testosterone levels.

How does Clomiphene work?

The pituitary gland in your brain releases various hormones into your circulation to assist with reproduction. Clomiphene is a medication that is used to stimulate the release of endocrine hormones from the pituitary gland, which leads to an increase in testosterone and sperm production in the testes. Increased levels of reproductive hormones like testosterone and sperm will alleviate hypoandrogenism (low testosterone) symptoms, as well as potentially improve non-obstructive azoospermia, which is a blockage that prevents the sperm from entering the semen.

How effective Is Clomiphene?

Men with hypoandrogenism have had significant improvements in testosterone and strength, as well as reduced tiredness and improved erectile function, according to large-scale research. After three months of taking clomiphene, up to 10% of azoospermic men experienced a resurgence of sperm in their ejaculate.

Clomiphene side effects

If you take Clomiphene, side effects may include the following:

  • Changes in libido (sex drive)
  • Changes in mood
  • Changes in energy level
  • Increased aggression
  • Male-patterned baldness
  • Blurred vision
  • Headaches
  • Increase in hemoglobin (a blood protein that transports oxygen and adds viscosity, or thickness, to your blood)
  • Enlargement of the prostate gland
  • Pectoral (or breast muscle) tenderness
  • Mild acne

What Is Anastrozole?

follicle stimulating hormone

Anastrozole (or Arimidex) is a hormone therapy that was originally designed to treat breast cancer but has now been used off-label in specific subsets of infertile men. Anastrazole works by blocking aromatase, an enzyme that prevents testosterone from transforming into estrogen. As a result, testosterone levels rise and estrogen levels fall.

During your therapy, we will check your hormone levels and testosterone to estradiol ratio in order to assess the drug’s efficacy.

How effective Is Anastrozole?

Anastrozole has been found to treat symptoms of male hypoandrogenism, such as fatigue, loss of muscle mass, decreased libido, and erectile dysfunction. It’s also been observed to improve sperm generation and recovery rates in men who are azoospermic or have a low sperm count.

Anastrozole side effects

You may experience adverse effects while taking Anastrozole, such as:

  • Nausea
  • Insomnia
  • Bone pain
  • Cough
  • Increased red blood cell count
  • Increased liver enzymes 

And rare but serious side effects that have been reported include:

  • Blood clots
  • Cataracts
  • Stevens-Johnson Syndrome is a serious crash caused by a drug intolerance

What is human chorionic gonadotropin (hCG)?

Human chorionic gonadotropin (hCG) is a hormone therapy that can be used to boost testosterone levels in males who have symptoms of low testosterone or hypogonadism. This medicine is usually a last resort treatment because it entails two to three injections each week, which many patients would rather avoid.

How does hCG work?

Human chorionic gonadotropin works by stimulating the testes to make their own testosterone and improve sperm production. It’s critical to maintain natural testis testosterone creation since it helps to preserve testis size and sperm output.

If your sperm count hasn’t improved after six months, we may suggest human menopausal gonadotropin (hMG) injections to your program. Menotropins are a combination of hormones made by the pituitary gland that aid in the function of your reproductive system. To see results, you may need to take these medicines together for up to 12 more months.

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How effective Is hCG?

treatment of male infertility

In hypogonadal men, hCG has been found to boost energy, desire, strength, and mood. This has been observed in men with unknown causes of hypogonadism as well as those who have reduced testosterone production owing to long-term testosterone replacement therapy. According to research published in Human Reproduction Update, the increase in testosterone production from hCG may also improve the chance of sperm retrieval in males with non-obstructive azoospermia.

hCG side effects

Side effects may include the following:

  • Pain at the injection site
  • Changes in libido (sex drive)
  • Changes in mood
  • Changes in energy level
  • Weight gain
  • Increased red blood cell concentration and risk for blood clots
  • Prostatic enlargement

What is Coenzyme Q10?

hormonal treatment

Coenzyme Q10 is a molecule that we make in our bodies from eating food or taking it as a nutritional supplement. It’s also an excellent antioxidant, which has been shown to assist with a number of illnesses, including male fertility

How effective is Coenzyme Q10?

It has been found to improve both sperm integrity and mobility in men with abnormal sperm parameters. It may also help people with pyospermia, a high number of white blood cells in the semen. It’s critical to follow up with testicular ultrasounds and doctor’s visits to see whether the treatment is working.

Coenzyme Q10 side effects

Coenzyme Q10 can still have adverse effects even if it is a vitamin. Even though Coenzyme Q10 is a supplement, there might be negative consequences from taking it in higher amounts. The following are some of the possible side effects:

  • Itching or rash
  • Nausea or vomiting
  • Headache
  • Low blood pressure
  • Altered heart rate
  • Insomnia
  • Cough
  • Decreased appetite

Please notify our staff if you are having any adverse effects as a result of taking these medicines. We may be able to adjust your dosage or add other medications to help reduce these side effects.

Medication monitoring

We urge patients to come in for lab testing and a clinic visit after two weeks to ensure these drugs are effective.

We will check PSA (a prostate gland protein), hemoglobin, and testosterone levels at each of these appointments to verify that there are no unwanted side effects. We will maintain four-monthly visits for the first year while subsequently reducing your appointments to once a year.

What is human menopausal gonadotropin?

luteinizing hormone

It is a hormone produced by the pituitary gland called LH-FSH. It aids in the functioning of your reproductive system.

hCG and hMG are frequently used together in men with low testosterone levels to boost sperm production. Testosterone is made in the testes when they are stimulated by hCG. When compared to testosterone, hMG helps preserve testis size and sperm output.

How effective are hCG and hMG?

According to a study published in Human Reproduction Update, testosterone production may be increased by hCG as part of sperm retrieval in men with non-obstructive azoospermia. In hypogonadal males, hCG has been shown to enhance energy, desire, strength, and mood. Men who have low testosterone levels often use hCG and hMG together to help boost sperm production.

hCG and hMG side effects

Side effects may include the following:

  • Pain at the injection site
  • Changes in libido (sex drive)
  • Changes in mood
  • Changes in energy level
  • Weight gain
  • Increased red blood cell concentration and risk for blood clots
  • Prostatic enlargement

HCG and HMG can both lead to changes in libido. hCG may increase sex drive in some men, while hMG can reduce it in others. It is important to monitor any changes in libido while taking these drugs and report them to your doctor. hCG and hMG can both lead to changes in libido. hCG may increase sex drive in some men, while hMG can reduce it in others. It is important to monitor any changes in libido while taking these drugs and report them to your doctor.

HCG increases red blood cells, which leads to a higher risk of blood clots forming within the body’s circulatory system. Blood clotting is increased by hMG as well. Please contact us immediately if you experience any adverse effects such as sudden chest pain or shortness of breath that could be signs that a blood clot has formed somewhere inside your body (such as your lungs).

FSH therapy for male infertility in patients with hypogonadotropic hypogonadism

leydig cells

Male infertility is caused by a lack of stimulation of spermatogenesis by the gonadotropins FSH and LH in males with hypogonadotropic hypogonadism. The primary pathophysiological feature in idiopathic/isolated/congenital hypogonadotropic hypogonadism (IHH or CHH) and Kallmann syndrome is altered hypothalamic gonadotropin-releasing hormone production or secretion.

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Abnormalities in testosterone occur when the pituitary gland does not respond to stimulation in a normal manner, causing an enlargement of the pituitary gland. As a result of this, hypogonadism occurs with low testosterone serum levels and infertility owing to azoospermia or severe oligozoospermia as laboratory indications. Secondary GnRH insufficiency is another cause of the same pathology.

Hypogonadotropic hypogonadism can be caused by a variety of factors, including pituitary insufficiency due to tumors (particularly makro-prolactinomas), metastases of the pituitary, and the hypophyseal stalk. Other causes include post-surgical states, radiotherapy of the pituitary region, traumas, infections, hemochromatosis, vascular diseases, and others.

Hypogonadotropic hypogonadism occurs when the pituitary gland is unable to release enough LH and FSH. The clinical picture in these individuals is additionally impacted by any abnormalities of the other pituitary hormones.

For most of the patient’s life, exogenous testosterone replacement is the treatment of choice in males with hypogonadotropic hypogonadism owing to various pathophysiologic causes as previously stated. This therapy has been well-established for many years and is quite easy for male patients. It is also reasonably cheap.

If a woman’s and man’s testosterone levels are balanced, the therapy is discontinued.

Patients should then be given FSH therapies and, if necessary, a pharmacological testosterone-boosting therapy to stimulate intratesticular Leydig cell testosterone production.

Diaphragmatic pacing is reserved for patients who have a thoracoabdominal aortic aneurysm, and it has not yet been approved for male hypogonadotropic hypogonadism. Patients are typically treated with human chorionic gonadotropin (hCG) preparations, which have comparable bioactivity but not identical activity to LH. hCG has a longer elimination half-life than LH, so two injections per week can effectively treat patients.

Exogenous pulsatile GnRH may also be used to treat hypogonadotropic hypogonadism caused by hypothalamic abnormalities.

Today, only a few people with hypogonadotropic hypogonadism are treated with pulsatile GnRH because of the time-consuming and complex pulsatile therapy. The use of pulsatile GnRH in patients with hypothalamic hypogonadotropic hypogonadism has not been proven superior to FSH and hCG treatment. However, because of the lack of good well-designed, randomized prospective trials, it is difficult to come to a conclusion about which therapy for infertility is best for these individuals.

Clinical studies with hMG in combination with hCG therapy

Since then, patients with hypogonadotropic hypogonadism have been treated successfully with hMG and hCG to stimulate spermatogenesis and result in a successful pregnancy in their female partners. More than 20 years ago, Büchter et al. published one of the most comprehensive studies evaluating the treatment efficacy in people with various causes of hypogonadotropic hypogonadism.

The use of hMG in this study may be seen as one case study for hMG therapy in these patients since at that time, highly purified or recombinant FSH preparations were increasingly used instead in the andrology clinic. In Büchter and colleagues’ study, 21 persons with hypogonadotropic hypogonadism due to pituitary disease received hMG plus hCG treatment. Because multiple treatments were required in several of these individuals, 30 courses could be analyzed in the study analysis.

18 individuals with hypogonadotropic hypogonadism caused by hypothalamic diseases such as Kallmann syndrome or congenital hypogonadotropic hypogonadism were given hMG and hCG (18 cases, 20 treatment courses). Overall, 31 of the 50 hMG plus hCG treatments were used for assisted conception in the female partner and 19 of the 50 courses were used only for spermatogenesis induction.

The results of a recent study indicate that Spermatogenesis was stimulated in all of the 30 therapy courses (100%) in men with pituitary disease, ranging from azoospermia to sperm detection in the ejaculate. In males with a hypothalamic problem, gonadotropin stimulation-induced spermatogenesis in 18 of 20 treatment cycles (90%).

The length of treatment until the first detection of sperm in the ejaculate varied considerably. The average treatment time for individuals with a pituitary problem was 4 months (2-16 months), whereas it was 6 months (1-18 months) for those with a hypothalamic disease.

The time it took for a woman with pituitary or hypothalamic disorders to get pregnant was 10 months (2-46 months) and 8 months (1-15 months), respectively. In support of the publication by Büchter et al., this study included data on pregnancies that were not published previously.

Following gonadotropin treatment for 42 or 48 months, one woman with pituitary disease and one woman with hypothalamic disease experienced a second pregnancy. In patients with a pituitary disorder, hMG plus hCG therapy resulted in 18 pregnancies in 21 treatment cycles (86%) and 6 pregnancies in 10 treatment cycles (60%).

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This “causative” therapy for male infertility in individuals with hypogonadotropic hypogonadism, when compared to other contemporary treatments of infertility including assisted reproductive techniques (ART), was shown to be highly efficient.

Factors influencing the efficacy of treatment

Patients who are infertile and have hypogonadotropic hypogonadism may be treated with hMG plus hCG for long periods of time. The treatment, however, may last for months or even years before a successful pregnancy is achieved. Patients should be informed that hormone therapy might continue for several months or even years before the intended pregnancy is reached. As a result, it’s important to discover factors that influence treatment success.

In a recent study of 51 adult patients with hypogonadotropic hypogonadism who had undergone one treatment cycle with FSH (urinary or recombinant FSH) plus hCG, those who had acquired hypogonadotropic hypogonadism after puberty or experienced a pubertal arrest had superior therapy results.

Patients with post-pubertally acquired hypogonadotropic hypogonadism manifesting before the normal onset of puberty had larger final bilateral testicular volumes and higher final sperm concentrations than those with pre-pubertally acquired hypogonadism. Most importantly, the pregnancy rate of 62% was superior in patients with post-pubertally acquired hypogonadotropic hypogonadism compared to those with pre-pubertally developed hypogonadism (42%).

Furthermore, the time to conception among female partners of patients with post-pubertally acquired hypogonadotropic hypogonadism was considerably earlier (20.3 ± 11.5 months) than that in female partners of individuals with pre-pubertally acquired hypogonadism (43.1 ± 43.8 months).

In a meta-analysis of seven previously published studies, the researchers found that patients with greater baseline testicular volume and greater baseline inhibin B serum concentrations had improved therapeutic success. The identification of these prognostic factors is consistent with other clinical investigations by other research teams.

Conclusion thoughts

HMG for male fertility is a difficult subject to tackle, but it’s important to know what you’re up against. hMG and hCG are the hormones that will be used in your treatment plan. Hormones can help regulate sperm production by stimulating follicles on the ovaries or testes, as well as stimulating growth of sex glands themselves. You should also have an understanding of pituitary disease — which ranges from azoospermia (the absence of any sperm) to detection of sperm in ejaculate; hypothalamic problems ranging from gonadotropin stimulation-induced spermatogenesis with 18 out 20 cases (90%); post-puberty acquired hypogonadotropic hypogonadism before puberty had better therapy results.

Frequently asked questions

How long does hMG take to work?

HMG takes about six weeks to start working. hCG works much faster and can be used as a booster when semen quality has not improved after two months of hMG treatment.

Which tablet is best for increase sperm count?

Fertigyn hMG 10000 IU Injection is the most effective hMG tablet. This hMG injection helps in increasing sperm count by stimulating ovaries and testes to produce hormones that stimulate follicles on the ovary or testis, as well as growth of sex glands themselves. It also increases testosterone levels and improves male fertility in patients with low sperm count and motility. This hMG injection is also helpful in treating oligospermia, azoospermia, and cryptorchidism. You can buy Fertigyn hMG 10000 IU Injection online from our website at the best prices.

Can men take Menotropin?

Yes, hMG is a hormone that can be used by men to improve their fertility. hMG helps in the production of sperm and testosterone levels. It also helps in the treatment of oligospermia, azoospermia, and cryptorchidism. You can buy hMG online from our website at the best prices.

What is the best medicine for male infertility?

Menotropin hMG 10000 IU Injection is the most effective hMG tablet. This hMG injection helps in increasing sperm count by stimulating ovaries and testes to produce hormones that stimulate follicles on the ovary or testis, as well as growth of sex glands themselves. It also increases testosterone levels and improves male fertility in patients with low sperm count and motility. You can buy Menotropin hMG 10000 IU Injection online from our website at the best prices.

Which medicine is best for male fertility?

Menotropin hMG 10000 IU Injection is the most effective hMG tablet for male fertility. This hMG injection helps in increasing sperm count by stimulating ovaries and testes to produce hormones that stimulate follicles on the ovary or testis, as well as growth of sex glands themselves. It also increases testosterone levels and improves male fertility in patients with low sperm count and motility. You can buy Menotropin hMG 10000 IU Injection online from our website at the best prices.

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